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Zero moderation. I know that /co/ on its worst day will still be far better than /v/ at its best, but having the mods pay attention to this board every once in a while would be nice.
People who get mad at general threads; the lack of a specific topic is a small price to pay for the prevention of board flooding.
Ever been to /d/? At any given time, they'll have from two to seven futa threads on the front page. It blocks out a lot of less popular fetishes, because everyone makes their own thread instead of consolidating. Now imagine what the front page of /co/ would look like without generals - three poni threads, two for Homestuck, two for Regular Show, and the rest would probably be Batman. This board is so heavily dependent on whatever happens to be the flavor of the week that the only way to make sure that less popular topics ever get discussed is by concentrating the larger fanbases into a long series of threads rather than many shorter ones. That's where generals come in.
Spammers, because they never seem to get banned for their faggotry. See point #1.