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[1238430058] Biology!

Anonymous Mon 30 Mar 2009 20:20:00 No.43004 View View Reply Original Report

Quoted By:

Does anybody know where PCNA is located, I can't fucking find shit (thanx, Google). Also, does anybody know how the killing effects of UV light work vs. the mutagenic effects? I'm assuming, the former causes disruptions in metabolism whereas the other one acts by causing pyrimidine dimers in DNA.

Anonymous

2

Anonymous Tue 31 Mar 2009 05:04:00 No.43014 Report

Quoted By:

PCNA is in the nucleus of eukaryotic cells.

What do you mean by killing effects? Do you mean UV induced apoptosis via DNA damage?

Anonymous

3

Anonymous Wed 01 Apr 2009 01:59:00 No.43059 Report

Quoted By:

Well, that's what I'd assume. That there is so much damage to the DNA that either apoptosis occurs or no amount of translesion synthesis can replicate past the amount of present dimers.

Anonymous

4

Anonymous Wed 01 Apr 2009 02:54:00 No.43064 Report

Quoted By:

If you're looking for some fun, look up proteins P53 and Rb. Interesting reads really.

Anonymous

5

Anonymous Wed 01 Apr 2009 04:44:00 No.43065 Report

Quoted By:

>>3

Apoptosis can occur because of substantial DNA damage, which is what happens in UV induced apoptosis.

Even if apoptosis doesn't occur and DNA damage gets through, it's possible that the damaged DNA codes for proteins vital to the proper function of cell (eg. metabolism, cell surface proteins, enzymes...) that could cause toxicity within the cells formed after mitosis. This toxicity could then cause the new cells to enter apoptosis.

Or it could cause mutations in oncogenes or tumour suppressor proteins, progressing that cell line towards an oncogenetic future.

If you're interested in cancer biology then have a look at this paper: http://www.google.co.uk/url?sa=t&source=web&ct=res&cd=1&url=http%3A%2F%2Fwww.weizmann.ac.il%2Fhome%2Ffedomany%2FBioinfo05%2Flecture6_Hanahan.pdf&ei=orjSSbOqBszF-QawlJXVBA&usg=AFQjCNHirXaVMmdQNGl-72bk5jRva4106Q&sig2=9xpUMCLeOUymZZ6F-5UD5g

Good stuff.

Anonymous

6

Anonymous Sat 01 Feb 2014 22:47:00 No.56671 Report

Quoted By:

FoxTrot BY BILL AMEND

Dr Ting : "WELCOME BACK TO BIOLOGY CLASS. I TRUST YOU ALL ENJOYED THE WINTER BREAK.

NOW THEN, WHO CAN TELL ME WHERE WE LEFT OFF BEFORE THE HOLIDAYS?

ANYONE?

MITOSIS? MEIOSIS? EITHER OF THOSE RING A BELL?

NO? HOW ABOUT GENETICS? MENDELIAN INHERITANCE? FRUIT FLIES? ANY OF YOU RECALL OUR DISCUSSING THOSE?"

Silence

Dr Ting : "WHAT ABOUT ALGAE?... PERHAPS SOMETHING ABOUT ALGAE?..."

Nicole : "(PSST) I'M TELLING YOU PAIGE, I DON'T THINK HE REMEMBERS!"

Paige : "SIR? I BELIEVE WE WERE ON CHAPTER ONE."

Classmate behind : "EARLY CHAPTER ONE!'

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