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I carry a G27 in .40
I have no problems with it. EDC is a tricky thing, you wanna carry the most effective round you can comfortably. But magazine capacity is also an important issue. I don't feel comfortable with a 9 and the .45's are too big for me to conceal, plus the .40 has better capacity then the .45
.45 is my range gun though.
Winchester PDX1 for the .40 is a great round btw, FBI uses it