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Don't use an STC, an STC fragment, rumours of an STC using civilization or anything STC related. It's been overdone.
Long lost ships from a forgotten age are always good. Either old Imperial ships or Dark Age of Technology stuff. Hunting down the remains of a crusade that was lost in the unexplored regions beyond the Imperium can form the basis of an entire campaign, especially if the fleet fractured and ended up in several different systems.
Talking of systems, how about that; treasure systems. Full of mineral wealth, xenotech, archaeotech, unusual lifeforms and so on. All trace of them has been lost, save for the rantings of drunks and a badly damaged astromantic chart. Lure of the Expanse is based on such a scenario.
