>>18851865autofire can get pretty nasty though, you don't deal with deviation so the Hornet's Nest is a viable CQB option for any 40mm launcher; also the launcher as a stand-alone or accessory isn't a longarm so you don't take the -4 penalty for firing on an adjacent target, but by that logic neither do MG gunners and LAW operators; then again, leveling any of these things on an assailant in close range is bound to produce hesitation enough to negate the penalty... possibly.
Second, autofire targets squares and so only has an AC of 10 rather than the target's AC, which is bound to be much higher.
Third the target then must save against Reflex DC15, which IIRC he doesn't get or is heavily penalized on if surprised, which is possible to probable in a fast-paced CQB situation. The only downside is that you're dealing 2d4 damage, the upside is, again, not deviation on the blast of rounds, and also that you're targeting four 5x5 squares which can contain multiple targets each (four guys lined up at a long firing port could take up ~10ft of space or less) all of which take that damage for a potential 16 targets in a seriously crowded room. given that most NPCs aren't going to be more than 2nd or 3rd level means an upper maximum of about 45hp on the toughest guys with the average toughest hitting around 28 for the toughest on the average, with more typical targets being more likely to average 9 or 10 overall by 2nd level.
With my personal twist on Vit & Wounds, they'd be down an average of 5 wounds if surprised, out of the typical 10w that's a -5 penalty to all checks, saves, rolls, and melee damage with a good chance of being unconscious and bleeding out.