>>147229718I'll answer this question.
I have had severe issues with amblyopia growing up, and I've had two corrective surgeries performed in 2004 and 2005 to help relieve the problem, but it's still not a complete fix. My eyes still don't align the way they're supposed to.
However, I can play the 3DS and enjoy some of the 3D aspects. For example, when I play Pilotwings: Resort, I can feel the plane contrails coming toward me, and the plane is closer to me than the rest of the environment, or Super Mario 3D Land, where I can see Mario seemingly jump off the screen in an overhead sort of way, and I can see fireballs shoot right toward me.
However, I think I'm not able to detect depth all that much.